Monotherapy of epilepsy in women: psychiatric and neuroendocrine aspects
Zheleznova, E.V.; Kalinin, V.V.; Zemlianaia, A.A.; Sokolova, L.V.; Medvedev, I.L.
Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 108(10): 43-48
2008
ISSN/ISBN: 1997-7298 PMID: 19008851 Document Number: 620013
An aim of the study was a comparative evaluation of efficacy and safety of traditional and modern antiepileptic drugs in women of reproductive age. A main group of patients consisted of 65 women, including 48 patients with partial epilepsy and 17 - with idiopathic generalized epilepsy. Some issues are solved in the study of a larger group comprising 110 patients (65 female and 45 male). The following drugs have been studied: topamax, valproates, carbamazepines and barbiturates. All of them were used as a monotherapy. Patient's state was assessed using clinical, neuropsychological and hormonal parameters. A general conclusion is that topamax is most beneficial, comparing with other drugs studied, in the treatment of women with epilepsy.