The use of toreal in the monotherapy of epilepsy in adults
Bondarenko, I.I.; Kissin, M.I.
Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 109(2): 35-39
2009
ISSN/ISBN: 1997-7298 PMID: 19365370 Document Number: 630907
Thirty patients with different forms of epilepsy were treated with toreal in dosage 200 mg per day. The clinical efficacy was assessed after 8 and 12 weeks. Side-effects and changes of laboratory parameters were assessed taking into account their intensity, duration and possible relation to the drug. Toreal was most effective in symptomatic local forms of epilepsy (76-95%) and less effective in idiopathic forms (up to 70%). In the period of dose titration, higher fatigue (70%), sleepiness (53.33%) were recorded more often than dizziness, paresthesias, dry mouth, diplopia, dyspepsia, ataxia and others side-effects. Higher fatigue remained in 70% of patients to the end of 12th week while the frequency of other side- effects has decreased. Overall, the severity of side-effects was mild that did not lead to changing of dose or drug's withdrawal.