Activation of expression of two immunoglobulin SN-genes in the American mink with Aleutian disease
Fomicheva, I.I.; Tsertsvadze, D.K.; Volkova, O.Iu.; Popova, N.A.; Smirnykh, S.I.; Kisteneva, N.A.; KuznetsovKN; Kudashev, V.F.; Kaveshnikov, I.D.
Genetika 27(5): 895-902
1991
ISSN/ISBN: 0016-6758 PMID: 1916255 Document Number: 368190
110 ranch-raised minks were injected with the Aleutian disease virus. Allotypes of constant regions of gamma-heavy chains of the mink immunoglobulins secreted have been analysed during 3 months. Activation of the expression of two markers (H3 and/or H4) up to minor or to nominal level (above 200 micrograms/ml) was observed. No such enhancement of expression of two other allotypes (H6 and H8) was found. The results suggest that the expression of two mink immunoglobulin CH genes induced by viral infection has allotype-specific regulation.