An immunoenzyme method for demonstrating Coxiella burnetii antigens
Gorbachev, E.N.; Tokarevich, N.K.; Verbov, V.N.; Kartseva, N.A.; Artiukhov, A.I.; Daĭter, A.B.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 2: 56-60
1991
ISSN/ISBN: 0372-9311 PMID: 1867036 Document Number: 367968
Materials on the development of an enzyme immunoassay (EIA) system for the detection of the antigens of C. burnetii, the causative agent of Q rickettsiosis, are presented. The system is highly specific and effective with respect to both corpuscular antigens of phases 1 and 2 and soluble antigen (lipopolysaccharide). The sensitivity of this method varies within the range 5-100 ng/ml. The effectiveness of EIA as a quantitative (semiquantitative) control test used in the process of the production of Coxiella preparations has been demonstrated.