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Effects of schizandrin B and schisanhenol on drug metabolizing-phase Ii enzymes and estradiol metabolism

Lu, H.; Liu, G.T.

Zhongguo Yao Li Xue Bao 11(4): 331-335

1990

ISSN/ISBN: 0253-9756
PMID: 2104487
Document Number: 367644
Intragastric gavage of schizandrin B (Sin B) and schisanhenol (Sal) 200 mg/kg once daily for 3 d significantly increased liver glutathione-S-transferase (GSH-S-T) and microsomal cytochrome P-450 in mice and rats. Sin B and Sal antagonized the increase of uterus weight induced by sc estradiol in ovariectomized, and decreased serum estradiol level in mice. RIA and HPLC showed an enhancement in [3H] estradiol metabolism by liver microsomes from Sin B- and Sal-treated mice. The results indicated that both Sin B and Sal have inductive actions on drug metabolizing-phase I and phase II enzymes in mice and rats.

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