Modulatory influence of Brassica compestris Linn var sarson on phase-Ii carcinogen metabolizing enzymes and glutathione levels in mice
Qiblawi, S.; Khan, A.K.; Rao, A.R.; Prashar, R.; Kumar, A.
Indian Journal of Experimental Biology 41(11): 1317-1321
2003
ISSN/ISBN: 0019-5189 PMID: 15332504 Document Number: 559613
The present study reports the modulatory influence of 95% ethanolic extract from the seeds of B. compestris on the activity of phase-II enzymes such as glutathione S-transferase (GST), DT-diaphorase (DTD) and reduced glutathione (GSH) level in the skin, lung, kidney and forestomach of the mouse. Oral treatment with the seed extract at 800 mg/kg body wt. for 15 days significantly elevated GST in lung and forestomach and DT-diaphorase in forestomach and skin and GSH level in lung, kidney forestomach and skin. The lower dose 400 mg/kg body wt was effective only in inducing GST and DT-diaphorase activity in forestomach and reduced glutathione level in lung. The findings suggest that B. compestris seed extract may block or suppress the events associated with chemical carcinogenesis at least in part, by inducing metabolic detoxification of the carcinogen.