Modulatory influence of oral contraceptives on mammary growth pattern of normal and ovariectomised mice
Ecavade, A.; Rao, A.R.
Contraception 50(2): 175-183
1994
ISSN/ISBN: 0010-7824 PMID: 7956216 DOI: 10.1016/0010-7824(94)90053-1Document Number: 286935
The present study reports the modulatory influence of oral contraceptive formulations, Ovral (0.05 mg ethinylestradiol plus 0.5 mg norgestrel per pill), Noracycline (0.05 mg ethinylestradiol plus 0.1 mg lynestrenol per pill), Pearl (0.03 mg ethinylestradiol plus 0.30 mg norgestrel) and Centchroman (30 mg), on the growth and developmental pattern of murine mammary epithelium in normal as well as ovariectomized mice. Oral treatments of ovariectomized mice for 15 days with doses D-1 (1/5-th of a pill) and D-2 (1/10-th of a pill) of Ovral, Noracycline and Pearl enhanced the diameter of the terminal end buds (TEBS) and lateral buds (LBS) significantly. The increase in the diameters of TEBS and LBS on treatment with similar doses of Centchroman were not much significant. Hence, it may be concluded from the present study that the growth and development pattern of mammary epithelium can be modulated by treatment with oral contraceptives Oral, Noracycline, Pearl and Centchroman which is indicated by the increase in the diameters of TEBS and LBS.
Document emailed within 0-6 h
