The antihypertensive effect of a new beta-blocking drug timolol in combination with hydrochlorothiazide

Pyörälä, K.; Mattila, S.; Leirisalo, M.; Toivonen, S.

Duodecim; Laaketieteellinen Aikakauskirja 92(11): 588-596

1976


ISSN/ISBN: 0012-7183
PMID: 7444
Document Number: 3663
A double-blind crossover evaluation of the antihypertensive effect of timolol as compared with placebo has been made in a series of 24 patients with mild or moderate hypertension, and who were receiving hydrochlorothiazide, 50 mg daily, as their basic treatment. A 10week pretrial period included 2 weeks on placebo, 4 weeks on hydrochlorothiazide alone, and a 4-week period during which the dosage of timolol was titrated for each patient. The daily timolol dosage thus determined, and subsequently used in the double-blind study, was 15 mg for 14 patients, 20 mg for 4 patients, 25 mg for 5 patients, and 30 mg for 1 patient. The double-blind crossover phase consisted of two 6-week periods during the course of which the patients received either timolol and hydrochlorothiazide, or placebo and hydrochlorothiazide. The mean values for systolic and diastolic blood pressure, in both the supine and standing position, and for heart rate were significantly lower during timolol-hydrochlorothiazide treatment than during placebo-hydrochlorothiazide treatment. Normotension was achieved during timolol-hydrochlorothiazide treatment in 15 of the 24 patients, but in only 5 of the 24 patients during placebo-hydrochlorothiazide treatment. Mild side-effects were slightly more common during timololhydrochlorothiazide treatment than during placebohydrochlorothiazide treatment. It appears that timolol, in combination with a thiazide diuretic, is an effective and welltolerated treatment in mild or moderate hypertension.

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The antihypertensive effect of a new beta-blocking drug timolol in combination with hydrochlorothiazide