The antihypertensive effect of a new beta-adrenergic blocking drug metroprolol in combination with chlorthalidone
Jäättelä, A.; Pyöräiä, K.
Duodecim; Laaketieteellinen Aikakauskirja 92(11): 597-603
1976
ISSN/ISBN: 0012-7183 PMID: 7445 Document Number: 3662
A double-blind crossover evaluation of the antihypertensive effect of metoprolol as compared with placebo has been made in a series of 23 patients with mild or moderate essential hypertension, who were receiving 25 mg chlorthalidone daily as their basic treatment. An individually titrated metoprolol dosage was used. The daily dose of metoprolol was 75 mg for 2 patients, 150 mg for 7 patients, 225 mg for 10 patients, and 300 mg for 4 patients. The double-blind crossover study consisted of two 3-month periods, during the course of which patients received either metoprolol or placebo in addition to chlorthalidone. Metoprolol, as compared with placebo, produced a statistically significant reduction of blood pressure, in both supine and standing positions. Normotension was achieved during metoprolol-chlorthalidone treatment in 22 of the 23 patients, but during placebo-chlorthalidone treatment in only 12 of the 23 patients. Mild side-effects became apparent during metoprolol-chlorthalidone treatment in 14 patients during the first month, in 12 patients during the second month, and in 7 patients during the third month. During placebo-chlorthalidone treatment side-effects occurred in 7, 6, and 7 patients, respectively. The conclusion can be drawn that metoprolol in combination with a diuretic appears to be an effective and well-tolerated treatment for mild or moderate hypertension.
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