The effect of catecholaminergic agents on the efficacy of immunostimulants
Shigaev, N.I.; Lazareva, D.N.
Farmakologiia i Toksikologiia 53(6): 33-36
1990
ISSN/ISBN: 0014-8318 PMID: 1981988 Document Number: 364739
The influence of combinations of immunostimulants (prodigiosin, methyluracil, levamisole) and catecholaminergic agents (dopamine, haloperidol, noradrenaline, phentolamine, isoproterenol, propranolol) on the results of antibiotic therapy of acute generalized Proteus infection and primary immune response to ram erythrocytes was studied on outbred albino mice. It was established that the agents influencing dopaminergic, alpha- and beta-adrenergic receptors can in some cases change the efficiency of the studied immunostimulants. The direction and degree of their action depend on the administration schedule.