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Effect of catecholaminergic substances on the proconvulsive properties of the caudate nucleus

Avakian, R.M.; Arushanian, E.B.

Biulleten' Eksperimental'noi Biologii i Meditsiny 80(8): 66-69

1975

ISSN/ISBN: 0365-9615
PMID: 171015
Document Number: 90916
In the freely moving rats stimulants of catecholaminergic tramission (DOPA, apomorphine, d,1-amphetamine, and also their combination with disulfiram) reduced the proconvulsive properties of the caudate nucleus. Under the effect of these substances there occurred a shortening of the cortical electroencephalographic response to a single stimulation of the nucleus in the animals given subconvulsive doses of pentaxylenetetrazol and a reduction of the extent of the spike-wave rhythm induced by the repeated caudate stimuli. On the contrary, inhibitors of catecholaminergic transmission (chlorpromazine, haloperidol, alpha-methyltyrosine and disulfiram) intensified the proconvulsive effect of the caudate nucleus.

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