Fluoxetine and its two enantiomers as selective serotonin uptake inhibitors
Wong, D.T.; Fuller, R.W.; Robertson, D.W.
Acta Pharmaceutica Nordica 2(3): 171-180
1990
ISSN/ISBN: 1100-1801 PMID: 2200429 Document Number: 363487
The biochemical and pharmacological profiles of R,S-fluoxetine and its R and S enantiomers have been compared and reviewed. Both enantiomers exhibit profiles analogous to R,S-fluoxetine as inhibitors of serotonin uptake in vitro and in vivo with about equal potencies or a eudismic ratio near unity.
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