Effects of alfentanil and fentanyl on induction of anaesthesia in patients with severe pregnancy-induced hypertension
Rout, C.C.; Rocke, D.A.
British Journal of Anaesthesia 65(4): 468-474
1990
ISSN/ISBN: 0007-0912 PMID: 2123395 Document Number: 362908
Forty patients with severe pregnancy-induced hypertension presenting for Caesarean section under general anaesthesia were allocated randomly to receive either fentanyl 2.5 .mu.g kg-1 or alfentanil 10 .mu.g kg-1 as part of the anaesthetic induction sequence. In all patients, the cardiovascular response to tracheal intubation was measured. Both drugs attenuated the response equally but did not abolished it in all patients. Alfentanil 10 .mu.g kg-1 is a suitable alternative to fentanyl 2.5 .mu.g kg-1 for patients with pregnancy-induced hypertension.