Comparison of erythrocyte membrane Ca2 (+) -Mg2 (+) -ATPase activity in children with and without family history of essential hypertension
Cheng, H.Y.; Liu, L.S.; Zheng, D.Y.
Journal of Human Hypertension 4(2): 147-148
1990
ISSN/ISBN: 0950-9240 PMID: 2140135 Document Number: 359324
The causes of elevated intra-erythrocyte calcium in the offspring of essential hypertensive patients are unknown. Fourteen children with and without a family history of essential hypertension were chosen to compare erythrocyte membrane Ca2(+)-Mg2(+)-ATPase activity (Rbc-M Ca2(+)-Mg2(+)-ATPase activity) measured by biochemical methods. We found that Rbc-M Ca2(+)-Mg2(+)-ATPase activity was lower in children with family history of hypertension compared with children with no family history (2.16 +/- 1.10 vs 3.36 +/- 1.19 microM Pi/mg protein/hour P less than 0.01). These results suggest that the reduced Rbc-M Ca2(+)-Mg2(+)-ATPase activity may be one of the mechanisms causing the high erythrocyte calcium levels in the offspring of essential hypertensive patients.