Hexachlorophene-induced changes in erythrocyte membrane ATPase activity
Lorusso, D.J.; Miller, T.L.
Research Communications in Chemical Pathology and Pharmacology 31(2): 205-216
1981
ISSN/ISBN: 0034-5164 PMID: 6452671 Document Number: 182071
Hexachlorophene (HCP) has been found to dramatically affect erythrocyte membrane ATPase activity. The Na+,K+,Mg2+-ATPase of erythrocyte membranes was strongly inhibited by HCP. The Mg2+-ATPase was stimulated at lower concentrations of HCP, while at higher concentrations of HCP the activity decreased toward control levels. Inclusion of bovine serum albumin in the incubation medium protected each enzyme from the effect of HCP. A possible mechanism for the alteration of erythrocyte membrane ATPase activity by HCP is presented.