Blood levels of opioid peptides and alpha interferon under the action of dipyridamole
Balashov, A.M.; Surkina, I.D.; Gotovtseva, E.P.; Petrichenko, O.B.; Panchenko, L.F.
Biulleten' Eksperimental'noi Biologii i Meditsiny 109(5): 462-464
1990
ISSN/ISBN: 0365-9615 PMID: 2143090 Document Number: 358943
The levels of met-enkephalin (ME), beta-endorphin (BE), and alpha-interferon (a-IFN) have been determined in the human blood 1 day after dipyridamole administration. Dipyridamole led to an increase in serum a-IFN concentration up to 3 times, and to simultaneous rise of the lymphocytes ability to produce a-IFN. The content of BE did not depend on dipyridamole treatment, but ME level achieved 110 +/- 4.8 pg/ml (compare to 79.5 +/- 7.6 pg/ml in control). Positive interrelation has been found out between individual ME concentrations and lymphocyte abilities to a-IFN production with the coefficient of correlation equal to 0.69. The effect of dipyridamole on ME level is suggested to develop via a-IFN interaction with the opioid systems.