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Action of interferon alpha and beta on four human melanoma cell lines in vitro

Köpf, J.; Hanson, C.; Delle, U.; Weimarck, A.; Stierner, U.

Anticancer Research 16(2): 791-798

1996

ISSN/ISBN: 0250-7005
PMID: 8687130
Document Number: 467538
Four human melanoma cell lines with different copy numbers of chromosomes 9 and 21q, as studied by the G-band technique, fluorescent in situ hybridisation (FISH) and Polymerase chain reaction (PCR), were tested for their sensitivity to Interferon-alpha (IFN-alpha) and Interferon-beta (IFN-beta) in relation to dosage of interferon genes (#9) and interferon receptor genes (#21p). The two most sensitive cell lines were those containing the highest numbers of #9 per cell, while the number of #21q copies (receptor genes) seemed to have no influence on the interferon sensitivity.

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