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Valine substitution

Lalaiants, I.E.; Milovanova, L.S.

Biofizika 35(2): 231-235

1990

ISSN/ISBN: 0006-3029
PMID: 2196088
Document Number: 357044
The review deals with analysis of the literature data concerning the importance of valine substitution in certain proteins, namely p21 ras and hemoglobin. A model of the active site of p21 protein is discussed in the light of GTPase activities alterations as a result of monoaminoacid substitution in conservative sites of p21 protein. The established relationship between some forms of transformation and Plasmodium falciparum malaria on the molecular level is shown in a new aspect. The widespread opinion that Hb S is valid as the means of malaria resistance is questioned in terms of new molecular data.

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