The effects of some nonpolar aminoacids--valine, leucine--administration on the arterial wall already exposed to a hypercholesterolemic diet
Cojocaru, E.; Zamfir, C.L.ăc.ăm.; Lupuşoru, C.ăt.ăl.E.; Cotuţiu, C.
Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 114(2): 504-509
2010
ISSN/ISBN: 0048-7848 PMID: 20700993 Document Number: 645063
Hypercholesterolemia plays an important role in atherosclerosis. The dietary supplementation of proteins or specific aminoacids seems to enhance the immune status in animals and humans with a complex pathological status, decreasing morbidity and mortality. In the present study we intended to analyse the effects of some nonpolar aminoacids--valine and leucine on cholesterol blood levels in a high-fat-diet in rats. In the same time we evaluated the vascular walls impact produced by the hypercholesterolemic diet. Our experiment was realised on 32 male Wistar rats, which were fed with cholesterol, valine and leucine for 8 weeks. At the end of experiment we analysed serum levels of cholesterol and also histopathological features of hypercholesterolemia on the arterial wall. The results of our study indicate that valine and leucine decrease the serum cholesterol and therefore the hypercholesterolemic-induced prooxidant status of the body being useful in reducing atherosclerosis.