Determination of the purity of valine by isocratic liquid chromatography coupled with charged aerosol detection (CAD)

Lodi, A.; Angus, M.; Nap, C.J.; Skellern, G.; Nicolas, A.; Lodi, A; Angus, M; Nap, C.J; Skellern, G; Nicolas, A

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Determination of the purity of valine by isocratic liquid chromatography coupled with charged aerosol detection (CAD)

Lodi, A.; Angus, M.; Nap, C.J.; Skellern, G.; Nicolas, A.

Pharmeuropa Bio and Scientific Notes 2015: 11-18

2015

ISSN/ISBN: 2075-2504

PMID: 26830156

Document Number: 679318

A liquid chromatography coupled with charged aerosol detection (LC-CAD) procedure; capable of separating and quantifying the most common impurities of valine at levels as low as 0.05 per cent (m/m), has been developed. The procedure is simple (isocratic), rapid, linear, sensitive and repeatable. It employs a widely available and inexpensive stationary phase (C18).