Changes in surface activity of surfactant and ultrastructure of the air-blood barrier in alcoholic intoxication in experimental animals

Zagorul'ko, A.K.; Birkun, A.A.; Fisik, E.E.; Safronova, L.G.

Biulleten' Eksperimental'noi Biologii i Meditsiny 109(5): 489-492

1990


ISSN/ISBN: 0365-9615
PMID: 2378966
Document Number: 356089
In the results of complex investigation of the lungs of 26 white rats, it was established, that there is the suppression of surface active properties of surfactant under influence of ethanol. In acute poisoning this suppression is associated with direct injury of surfactant with ethanol and inactivation of surfactant with serum proteins, which appear in the alveolar space because of the edema of air-haematic barrier. In prolonged influence the suppression of the surface activity of surfactant is due to the increase of its catabolism with alveolar macrophages.

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