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Immunomodulating properties of leukinferon

Iushchuk, N.D.; Zmyzgova, A.V.; Tugutova, I.V.; Kuznetsov, V.P.; Babaiants, A.A.; Novikova, T.A.; Eremina, O.F.; Mesniankin, A.P.; Lebedev, V.V.; V'iushina, M.A.

Sovetskaia Meditsina 7: 11-14

1990

ISSN/ISBN: 0038-5077
PMID: 2251550
Document Number: 355441
Tolerance and immunomodulating properties of leukinferon for injections were studied in 13 healthy volunteers. The drug was administered by inhalation and intramuscularly in a single dose of 10,000 MU twice daily for 3 days. Intramuscular injections of the drug were accompanied by a number of side effects: pyrogenicity, weakness, headache, that ceased 8-12 hrs after the drug was discontinued. Despite these side effects, the drug was satisfactorily tolerated. Neither viscera nor systemic disorders nor allergic reactions were detected. T-lymphocytes proved to be the most sensitive to the drug. Leukinferon was found to activate the interferon system. The effect was the most marked in respect of IRL-gamma.

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