Immunomodulating therapy of adjuvant disease in rats
Sibiriak, S.V.; Lazareva, D.N.; Khaĭbullina, S.F.
Farmakologiia i Toksikologiia 51(2): 72-74
1988
ISSN/ISBN: 0014-8318 PMID: 3378610 Document Number: 324582
During a comparative analysis of efficacy of prodigiosan and its combinations with cyclophosphamide (5 mg/kg), asathioprine (4 and 20 mg/kg) and delagil (25 mg/kg) it was shown that the most pronounced suppression of the adjuvant disease was observed in the group of animals given cyclophosphamide with prodigiosan. The suppression of arthritis with cyclophosphamide, prodigiosan and their combination was followed by a decrease of autosensibility parameters--hypersensitivity to collagen and the amount of immune rosette-forming cells in the regional lymph nodes.