Antioxidative properties of glycyrrhyzic acid salts and their effect on the liver monooxygenase system
Abdugafurova, M.A.; Li, V.S.; Sherstnev, M.P.; Atanaev, T.B.; Isamukhamedov, A.S.; Bachmanova, G.I.
Voprosy Meditsinskoi Khimii 36(5): 29-31
1990
ISSN/ISBN: 0042-8809 PMID: 2251786 Document Number: 355236
Antioxidative activity of potassium- and sodium glycyrrhizins was detected by means of chemoluminescence procedure. As shown by the spectral studies the glycyrrhizin salts formed complex of the I type with cytochrome P-450 from rat liver microsomes, inhibited inactivation of isolated cytochrome P-450LM2 and induced hemoprotein formation after administration into rats. The preparations of glycyrrhizic acid appear to be useful for treatment of toxic impairment of liver tissue.