The antioxidative defense system in the liver of rat fetuses upon antenatal exposure to lead
Uzbekov, M.G.; Karpachevskaia, I.K.; Bubnova, N.I.; Kulikova, G.V.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 1: 23-24
2003
ISSN/ISBN: 0031-2991 PMID: 12652940 Document Number: 564324
The activity of Zn, Cu-containing superoxide dismutase was studied in the liver of 20-day old fetuses of female rats exposed to different concentrations of lead in different periods and during pregnancy. There were significant changes in the enzyme activity depended on a used dose of lead and on the duration of exposure to this compound. Activation of free radical processes and impairment of the antioxidative defense system are likely to be one of the basic mechanisms responsible for hepatic damage during prolonged antenatal lead intoxication.