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Effect of diets with different carbohydrate/fat ratios on the cytochrome P-450 content and monooxygenase activity of rat liver

Zaboĭkina, T.N.

Voprosy Pitaniia 3: 59-60

1984

ISSN/ISBN: 0042-8833
PMID: 6474954
Document Number: 236159
Wistar male rats kept on high-protein (36% protein) diets for 30 days showed an increase in the content of cytochrome P-450 and b5 in liver microsomes, which was accompanied by an increase in the rate of amidopyrine and aniline oxidation. The degree of induction of the monooxygenase system of the liver endoplasmic reticulum with phenobarbital (100 mg/kg bw daily for 4 days) in rats which received high-protein diets was lower than in control and depended on the carbohydrate/fat ratio in the diet.

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