The effect of inducers of microsomal enzymes on glucose transport in the kidneys
Ul'ianov, G.P.; Lampatov, V.V.
Farmakologiia i Toksikologiia 53(1): 48-50
1990
ISSN/ISBN: 0014-8318 PMID: 2328799 Document Number: 353671
Phenobarbital (50 mg/kg), benzonal (35 mg/kg) and zixorine (100 mg/kg) administered orally for 4 days and 3-methylcholanthrene (20 mg/kg) administered subcutaneously for 2 days decreased the maximal tubular transport of glucose in rats. Phenobarbital (10 mg/kg) given orally for 8-10 days reduced the tubular reabsorption of glucose in dogs. An increase of phenobarbital dose enhanced and prolonged its effect on the renal tubular transport of glucose.