Effect of glucagon on bile acid after hepatectomy in patients with hepatocellular carcinoma associated with cirrhosis
Sudo, T.; Bessho, H.; Miyamoto, M.; Yasuda, C.; Uchida, T.; Kawamura, M.; Kuyama, T.
Nihon Geka Gakkai Zasshi 91(11): 1710-1714
1990
ISSN/ISBN: 0301-4894 PMID: 2177518 Document Number: 351547
Hepatic function frequently becomes worse, after hepatectomy in patients with hepatocellular carcinoma associated with cirrhosis. We usually use insulin and glucagon to treat patients with poor hepatic function, so we examined hepatic function in these patients in relation to bile acid metabolism. 1) Total serum bile acid levels were increased in patients with cirrhosis, and serum GCDCA, TCDCA values were especially high. After surgery, they rose even higher. 2) Glucagon was shown to stimulate C-AMP and decreased total serum bile acid, and especially serum GCDCA and TCDCA values.