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Studies of adaptation of influenza viruses to their replication in low temperature. I. Biological properties

Brydak, L.

Medycyna Doswiadczalna i Mikrobiologia 42(3-4): 122-130

1990

ISSN/ISBN: 0025-8601
PMID: 2084448
Document Number: 351160
Influenza A/H3N2/ virus strains derived from various isolations and replicated in lowered temperatures (37 degrees, 35 degrees, 33 degrees, 30 degrees) in chicken embryos were used for the study. An alteration of temperature optimum of neuraminidase activity was established after 12-15 passages of influenza virus in lowered replication temperature and it differed depending on tested strain. During adaptation process of viruses to lowered replication temperatures no correlation between neuraminidase activity and haemagglutinating titer was seen.

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