Significance of the acetylator phenotype and initial oral/intravenous rifampicin administration in the treatment of tuberculosis
Loos, U.; Musch, E.; Schwabe, H.K.
Pneumologie 44(Suppl 1): 488-489
1990
ISSN/ISBN: 0934-8387 PMID: 2367445 Document Number: 349681
In a pilot study involving 62 patients with open pulmonary tuberculosis, we established that slow acetyators and patients receiving intravenous rifampicin treatment showed a tendency towards a more rapid negativisation of the sputum culture than did fast acetyators (lower levels of isoniazid) or patients receiving oral rifampicin therapy (decreasing bioavailability of the rifampicin during treatment).
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