Axonal neuropathy and salazosulfapyridine: slow-acetylator phenotype
Blin, O.; Sangla, I.; Jouglard, J.; Cottin, C.; Pellissier, J.F.; Serratrice, G.
Revue Neurologique (Paris) 148(2): 154-156
1992
ISSN/ISBN: 0035-3787 PMID: 1351312 Document Number: 403959
We report a case of an axonal sensorimotor neuropathy involving salazosulphapyridine in a slow-acetylator patient with ulcerative colitis. Rather than hypersensitivity the mechanism of the neuropathy can be assumed to be toxicity. The role played by the respective different metabolites in the occurrence of this uncommon side effect is uncertain.
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