Kinetics of amiloride in rat following oral and intravenous administration

Runci, F.M.; Cerretani, D.; Bianchi, E.; Bruni, G.; Giorgi, G.

Bollettino della Societa Italiana di Biologia Sperimentale 65(10): 939-943

1989


ISSN/ISBN: 0037-8771
PMID: 2624711
Document Number: 331411
The disposition profile of amiloride, a potassium sparing agent, was studied in rats by using an HPLC method coupled to spectrofluorometric detection. Amiloride was administered orally and intravenously at the dose of 10 mg/Kg. The most relevant pharmacokinetic parameters are described for both administration routes.

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