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Effect of nicardipine on cerebral vasomotor activity in hypocapnia

Durand, M.; Combes, P.; Louveau, A.; Carcey, J.

Agressologie Revue Internationale de Physio-Biologie et de Pharmacologie Appliquees Aux Effets de l'Agression 31(5): 262-264

1990

ISSN/ISBN: 0002-1148
PMID: 2126914
Document Number: 349051
Nicardipine, a calcium channel antagonist derivative of dihydropyridine, is a cerebral vasodilatator used in the treatment of cerebral vasospasms induced by subarachnoid hemorrhage after rupture of intracranial aneurysm. Hypocapnia is a powerful vasoconstrictor of cerebral arteries, and antagonizes in the baboon the cerebral vasodilative effect of nimodipine, another derivative of dihydropyridine. The action of nicardipine in presence of hypocapnia was not yet study in human. The study of the interaction of nicardipine and hypocapnia on the cerebral arteries show that hypocapnia antagonizes the cerebral vasodilatator properties of nicardipine.

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