Top Abstract Purchase Related
Home
>
Node
>
Subnode

Effect of nootropic agents on impulse activity of cerebral cortex neurons

Iasnetsov, V.V.; Pravdivtsev, V.A.; Krylova, I.N.; Kozlov, S.B.; Provornova, N.A.; Ivanov, I.V.; Iasnetsov, V.V.

Eksperimental'naia i Klinicheskaia Farmakologiia 64(6): 3-6

2001

ISSN/ISBN: 0869-2092
PMID: 11871233
Document Number: 531009
The effect of nootropes (semax, mexidol, and GVS-111) on the activity of individual neurons in various cerebral cortex regions was studied by microelectrode and microionophoresis techniques in cats immobilized by myorelaxants. It was established that the inhibiting effect of mexidol upon neurons in more than half of cases is prevented or significantly decreased by the GABA antagonists bicuculline and picrotoxin. The inhibiting effect of semax and GVS-111 upon neurons in more than half of cases is related to stimulation of the M-choline and NMDA receptors, respectively.

Document emailed within 1 workday
Secure & encrypted payments

Batrak, G.E.; Zlenko, E.T.; Khrustalev, S.I. 1977: Changes in the impulse activity of neurons of the sensomotor zone of the cerebral cortex under the influence of morphine, premedol and fentanyl Farmakologiia i Toksikologiia 40(3): 264-267
Kovalev, G.I.; Vorob'ev, V.V.; Akhmetova, E.P. 1999: NMDA-dependent component in effects of pyracetam and GBC-111, the new peptide with the nootropic activity, on EEG in the cerebral cortex and hippocampus from non-narcotized rats Biulleten' Eksperimental'noi Biologii i Meditsiny 127(8): 190-193
Gaĭdamkin, N.A.; Davydov, B.I.; Zuev, V.G.; Tikhonchuk, V.S. 1988: Ultrastructure of the cerebral cortex in the rat after the effect of electromagnetic impulse Arkhiv Anatomii Gistologii i Embriologii 95(7): 14-18
Kamenev, A.L.; Samoĭlov, M.O.; Semenov, D.G.; Sofronov, G.A. 1991: Effects of oxymethacil on microcirculation and neuronal impulse activity in the cat cerebral cortex in acute fosfakol poisoning Biulleten' Eksperimental'noi Biologii i Meditsiny 112(8): 115-117
Suslov, N.I.; Churin, A.A.; Skurikhin, E.G.; Provalova, N.V.; Stal'bovskiĭ, A.O.; Litvinenko, V.I.; Dygaĭ, A.M. 2002: Effect of natural nootropic and adaptogen preparations on the cortex bioelectrical activity in rats Eksperimental'naia i Klinicheskaia Farmakologiia 65(1): 7-10
Gilerovich, E.G. 1979: Localization of ATPase in the cerebral cortex and its role in the functional activity of neurons Arkhiv Anatomii Gistologii i Embriologii 77(8): 22-29
Popova, E.N. 1979: Effect of alcohol on cerebral cortex neurons Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 79(12): 1674-1678
Le, T.L.; Chernositov, A.V. 1982: Effect of testosterone on the background impulse activity of the arcuate nucleus neurons of the hypothalamus Biulleten' Eksperimental'noi Biologii i Meditsiny 94(8): 5-6
Arushanian, E.B.; Belozertsev, I.A. 1973: The different effect of various portions of the caudate nucleus on the impulse activity of cortical sensory-motor neurons Biulleten' Eksperimental'noi Biologii i Meditsiny 75(3): 3-6
Nemtsov, A.V.; Dubinskaia, G.R. 1975: Effect of neuroleptics of the phenothiazine series on the impulse activity and ultrastructure of the cortical neurons of rabbits Biulleten' Eksperimental'noi Biologii i Meditsiny 79(4): 64-68
Akopian, N.S.; Baklavadzhian, O.G.; Sarkisian, N.V. 1993: Effect of hypothalamus and amygdala on the impulse activity of neurons of the medullary respiratory center in rats during hypoxia Aviakosmicheskaia i Ekologicheskaia Meditsina 27(3): 33-37
Ivanova, S.I.; Storozhuk, M.V.; Kostiuk, O.P.; Kostiuk, P.H. 2004: Effect of synaptic transmission blockade and hypoglycemia on neuron impulse activity in cultured rat hippocampal neurons Fiziolohichnyi Zhurnal 50(4): 16-21
Kruchenko, Z.O. 2009: The effect of D2-receptor blockade on the normal and stress-induced activity of the prefrontal cortex neurons in SHR rats Fiziolohichnyi Zhurnal 55(3): 100-108
Petkov, V.D.; Petkov, V.V.; Popova, J.; Konstantinova, E. 1987: Changes in the 5-HT-binding sites in the cerebral cortex, striatum and hypothalamus of rats during ageing and under the effect of dopaminergic agents Acta Physiologica et Pharmacologica Bulgarica 13(1): 11-19
Kositskiĭ, G.I.; Mikhaĭlova, S.D.; Semushkina, T.M. 1984: Impulse activity of the nodose ganglion neurons in myocardial ischemia Biulleten' Eksperimental'noi Biologii i Meditsiny 98(12): 653-655
Carrascal, E.; Campora, R.G.; Bullón, M.; Fernández, J.; Galera, S.H. 1977: Ultrastructure of the dark neurons of the cerebral cortex Archivos de Neurobiologia 40(3): 165-176
Solntseva, E.I.; Bukanova, I.V. 1998: Cyclic GMP mimicks potentiation effect of the nootropic agent vinpocetine on the high threshold A-current in the mollusk neurons Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 84(8): 741-746
Shandra, A.A.; Godlevskiĭ, L.S. 1983: Effect of electric stimulation of the fastigial nucleus on epileptic activity in the cerebral cortex Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 1983(6): 29-34
Popova, E.N. 2001: Ultrastructure of the cerebral cortex neurons in atherosclerotic dementia Morfologiia 119(2): 11-14
Dergacheva, O.I.; Khachikova, I.E.; Burikov, A.A. 2002: Impulse activity of neurons in the nucleus pontis oralis in cats during sleep--wakefulness cycle Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 88(12): 1530-1537