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Effect of neuroleptics of the phenothiazine series on the impulse activity and ultrastructure of the cortical neurons of rabbits

Nemtsov, A.V.; Dubinskaia, G.R.

Biulleten' Eksperimental'noi Biologii i Meditsiny 79(4): 64-68

1975

ISSN/ISBN: 0365-9615
PMID: 1191771
Document Number: 89309
Experiments on rabbits showed that chlorpromazine given in a dose of 5 mg/kg produced a disaggregation of polysomes, dilatation of the cysterns of the endoplasmic reticulum, hypertrophy of the Golgi apparatus and swelling of the mitochondria in the majority of the cortical neurons. To these ultrastructural changes corresponded the inhibition of the pulse activity of the nerve cells. In difference from chlorpromazine, trephthazine given in the same dose caused a thickening of the matrix of a part of the neurons, accompanied by an increase in the pulse activity of a group of the cortical cells (28%) under the effect of triphthazine. The established changes in the pulse activity and the ultrastructure of the neurons are regarded in association with the differences in the spectrum of the psychotropic activity of the two neuroleptics--phenothiazine derivatives.

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