Inhibition of growth and metastases of lung carcinoma in C57BL/6 mice by Corynebacterium parvum and its antitumor mechanism
Xiao, Y.; Lu, Y.; Zhang, J.; Cao, J.; Huang, X.
Hua Xi Yi Ke da Xue Xue Bao 21(3): 318-321
1990
ISSN/ISBN: 0257-7712 PMID: 2093073 Document Number: 348047
Cocrynebacterium parvum (CP) was injected around the tumor and tumor cells were inoculated subcutaneously with activated peritoneal macrophages. The effects on the growth and metastases of Lewis lung carcinoma in C57BL/6 mice were observed. Experimental results indicated that CP had significant inhibitory effect on the tumor growth and lung metastases. The cytotoxic effects of activated peritoneal macrophages in mice on target tumor cells (L5178Y) in vitro were studied with the technique of 3H-TdR assay. The proliferation of tumor cells was markedly inhibited by the activated peritoneal macrophages of CP. Experiments showed that the antitumor mechanism of CP was the mediation via activated cytotoxic macrophages. These results indicated that CP is an effective immunostimulant. These findings will provide a scientific basis for the clinical treatment of the primary and metastatic lung carcinoma.