Decreased liver and lung drug-metabolizing activity in mice treated with Corynebacterium parvum
Soyka, L.F.; Hunt, W.G.; Knight, S.E.; Foster, R.S.
Cancer Research 36(12): 4425-4428
1976
ISSN/ISBN: 0008-5472 PMID: 1000491 Document Number: 103640
Injections of killed suspensions of Corynebacterium parvum (i.p.) in young male mice were followed by time- and dose-dependent decreases in the drug-metabolizing activity of liver microsomes and lung homogenates. In vitro assays with model substrates [aminopyrine, aniline, p-nitroanisole, and benzo(a)pyrene] were used to quantitate drug-metabolizing activity. It is likely that such decreases in mixed function oxidases activity will act to significantly alter the pharmacokinetics of concurrently or subsequently administered drugs. The results provide a possible mechanism to explain several previously reported immunochemotherapeutic interactions.