Effects of a high-linoleate and a high-alpha-linolenate diet on spontaneous mammary tumourigenesis in mice
Kamano, K.; Okuyama, H.; Konishi, R.; Nagasawa, H.
Anticancer Research 9(6): 1903-1908
1989
ISSN/ISBN: 0250-7005 PMID: 2627137 Document Number: 346172
SHN mice were fed a high-lineleate diet, a high-.alpha.-linolenate diet or a control diet. Spontaneous mammary tumourigenesis was significantly inhibited in the high .alpha.-linolenate group compared to the other two groups, while little difference was observed among groups in the rates of lung metastasis. The dietary .alpha.-linolenate/linoleneate balance affected the fatty acid patterns of tissue lipids. The triacylglycerol/phospholipid ratios and the fatty acid patterns were significantly different between the mammary glands and the mammary tumours. The results indicate that the dietary .alpha.-linolenate/linoleate balance affects the fatty acids composition and, in turn, spontaneous mammary tumourigenesis in mice.