Spontaneous lymphomas in mice genetically selected for high or low phytohemagglutinin responsiveness
Covelli, V.; Di Majo, V.; Bassani, B.; Mancini, C.; Adorini, L.; Doria, G.
Journal of the National Cancer Institute 75(6): 1083-1090
1985
ISSN/ISBN: 0027-8874 PMID: 3877838 Document Number: 251387
Biozzi mice selected for high (Hi) or low (Lo) responsiveness to phytohemagglutinin (PHA) have been followed for their entire life-span to examine their pathology at death. Spontaneous lymphomas were found to exhibit higher incidence and faster development in Lo/PHA than in Hi/PHA females, whereas a similar difference between the two lines did not attain the level of statistical significance in male mice. The incidence of solid tumors was higher in Lo/PHA than in Hi/PHA males but the same in females of the two lines, yet the probability of dying from solid tumors was slightly increased in Lo/PHA mice of both sexes. All these results indicate that T-cell-mediated immunity influences mainly the spontaneous incidence of lymphomas and, to a lesser degree, the appearance of other solid tumors.