Relationship of immunoglobulins with the number & duration of schizophrenic episodes
Tiwari, S.C.; Lal, N.; Trivedi, J.K.; Varma, S.L.
Indian Journal of Medical Research 90: 229-232
1989
ISSN/ISBN: 0019-5340 PMID: 2767749 Document Number: 345667
The relationship of serum and CSF immunoglobulins with the number and duration of schizophrenic episodes was assessed in 40 schizophrenics. The mean IgA was increased in patients having 3 or more episodes as compared with those having the first episode (P < 0.001). IgM showed a moderate increase in patients with the second episode and those having 3 or more episodes. IgG/TP per cent (IgG/total protein %) was found to be significantly increased in CSF of patients having the first episode, as compared with those having 3 or more episodes (P < 0.001). IgG was increased (although insignificantly) in the CSF of patients with illness of five years duration as compared to patients having illness of one year duration or for illness between 1-5 yr. IgG/TP per cent was found to be significantly increased in patients have illness for 5 or more years when compared to patients having illness for less than 1 yr (P < 0.001) and for 1-5 yr (P < 0.01).