Relationship between perazine serum concentration and clinical results in long-term treated schizophrenic outpatients
Pietzcker, A.; Müller-Oerlinghausen, B.; Schley, J.; Chaskel, H.; Poppenberg, A.; Urban, R.
Arzneimittel-Forschung 28(8): 1302-1303
1978
ISSN/ISBN: 0004-4172 PMID: 37850 Document Number: 133267
The perazine serum concentration was determined with a new gaschromatographic method in 33 schizophrenic outpatients of our psychiatric catamnestic unit who had received perazine for a period of 18 years. A very high constancy of the perazine serum level could be demonstrated by repeated measurements. A close connection existed between perazine dosage and perazine serum level. Both findings suggest a very good complicance of these patients. Serum levels were correlated positively with the intensity of the psychopathologic symptoms as well as with the frequency of side-effects, particularly with slight changes of liver enzymes.