Relationship between ultrastructural pathology of the embryonal brain and features of the course and treatment of schizophrenic mothers
Orlovskaia, D.D.; Solov'eva, Z.V.
Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 80(11): 1682-1687
1980
ISSN/ISBN: 0044-4588 PMID: 7456920 Document Number: 161118
Evaluation of the ultrastructural changes in embryonic brain cells was made according to the intensity of two complexes--destructive and compensatory-proliferative. They were correlated with a number of clinical parameters (features of mother's disease, the condition at the moment of abortion, peculiarities of treatment, etc.). It was established that for schizophrenia, unlike other diseases, the compensatory-proliferative complex of changes is more typical. The most pronounced changes in brain ultrastructures were noted in embryos of the patients with acute psychotic states or in the decompensation stage in psychopathlike schizophrenia course. No correlation between the form of the disease course and intensity of mother's treatment was established.