Ultrastructural features of cerebral synapses in schizophrenic patients
Anders, V.N.
Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 78(7): 1065-1070
1978
ISSN/ISBN: 0044-4588 PMID: 685616 Document Number: 124547
The paper is concerned with ultrastructural traits of synapses in the frontal lobe, supraoptical nucleus of the hypothalamus and caudal nucleus of the brain in 12 schizophrenic patients and 8 normals (the period of autopsy was 4 hours following death). The results demonstrated 2 types of changes: 1) slightly expressed changes (a decrease of the extent of active zone contacts, changed forms in the synaptical vesicles); 2) extremely expressed or degenerative changes in the synapses (an appearance of fibrillar structures, glycogene granules, degeneration of synaptical endings of a dark type).