Preparation, properties and therapeutic potential of cytidine diphosphocholine incorporated into liposomes
Burlina, A.P.; Galzigna, L.
Rivista di Neurologia 59(1): 26-31
1989
ISSN/ISBN: 0035-6344 PMID: 2762734 Document Number: 345074
Cytidine diphosphocholine (CDC) was incorporated into unilamellar egg lecithin liposomes with a yield of 23% and subsequently administered to rats by intracardiac injection. Unlike free CDC, 0.2% of which was absorbed by the brain, 21% of the CDC-liposomes was absorbed by the brain, while their relative distribution among brain phospholipids was similar. The changes in blood concentration and brain content of CDC, with and without liposomes, were measured at different times after administration. The CDC-liposome association significantly increased, unlike CDC alone, the levels of dopamine catabolites in the striatum of rats treated with haloperidol (0.15 mg/Kg/die) after 5 days of intravenous administration (20 mg/Kg/die).