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Oxotremorine-induced cholinergic syndrome: modifications by levodopa and/or oral cytidine diphosphocholine

Saligaut, C.; Daoust, M.; Chadelaud, M.; Moore, N.; Chretien, P.; Boismare, F.

Methods and Findings in Experimental and Clinical Pharmacology 7(1): 5-8

1985

ISSN/ISBN: 0379-0355
PMID: 3990445
Document Number: 4411
A peripheral and cerebral cholinergic syndrome was induced in mice by oxotremorine administration; pretreatment orally with cytidine diphosphocholine (CDP-choline) does not potentiate this syndrome and even antagonizes oxotremorine-induced salivation. Levodopa antagonizes the oxotremorine-induced cerebral symptoms (akinesia + tremor); however this antagonism disappears when mice are chronically pretreated orally with CDP-choline, confirming the action of CDP-choline on dopaminergic pathways. The proven efficacy of CDP-choline in Parkinsonism could then be mediated by a hypersensitivity of some cerebral dopamine receptors, and not by a direct stimulating effect of the striatal dopaminergic receptors.

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Oxotremorine-induced cholinergic syndrome: modifications by levodopa and/or oral cytidine diphosphocholine

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