Dopamine deficiency syndrome in children with specific reaction to the treatment with levodopa preparations
Shoshina, L.M.; Grinio, L.P.; Mineeva, M.F.
Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 89(8): 27-32
1989
ISSN/ISBN: 0044-4588 PMID: 2573987 Document Number: 333630
The authors describe the dopamine deficiency syndrome in children with the disease beginning during their first year and peculiar dystonia++ symptoms resulting in a total immobilization and speech loss. All the symptoms of the disease can be removed by low doses of Nakom and reappeared upon the drug withdrawal. Tyrosine hydroxylase studies performed in these patients at various stages of the disease showed an unusual pattern of the enzyme activity differing from that seen in children with similar pathology failing to improve dramatically under the Nakom treatment.