Immune deficiency in the X-linked lymphoproliferative syndrome. I. Epstein-Barr virus-specific defects
Harada, S.; Sakamoto, K.; Seeley, J.K.; Lindsten, T.; Bechtold, T.; Yetz, J.; Rogers, G.; Pearson, G.; Purtilo, D.T.
Journal of Immunology 129(6): 2532-2535
1982
ISSN/ISBN: 0022-1767 PMID: 6292290 Document Number: 189152
Males (11) with XLP against EBV-infected cells was abnormally low in 6 patients and was elevated in 2 patients given .gamma.-globulin. ADCC titers did not correlate with anti-VCA titers. Most patients with XLP failed to effect regression of autologous EBV-infected lymphoblastoid cell lines, indicating a deficiency in long-lived T cell-mediated immunity to EBV.
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