Antiviral activity of amiksin incorporated into liposomes
Grigorian, S.S.; Simonov, A.N.; Ivanova, A.M.; Ershov, F.I.
Voprosy Virusologii 33(3): 302-305
1988
ISSN/ISBN: 0507-4088 PMID: 2459848 Document Number: 308203
The results of a comparative study of the antiviral activity of amyxin (tilorone) without liposomes and incorporated into liposomes on the model of experimental enteral hepatitis of mice are presented. The use of amyxin in liposomes was shown to prolong interferon production and to provide significant 60% protection of the animals. The possible mechanism of increasing the antiviral effectiveness of amyxin upon its incorporation into liposomes, enteral administration and subsequent enteral infection of mice with hepatitis virus is discussed. It is assumed that use of amyxin in liposomes may increase its effectiveness in prevention of human hepatitis A.