Analysis of yeast retrotransposon Ty insertions at the CAN1 locus
Wilke, C.M.; Heidler, S.H.; Brown, N.; Liebman, S.W.
Genetics 123(4): 655-665
1989
ISSN/ISBN: 0016-6731 PMID: 2558956 Document Number: 343555
The target site distribution for 55 independent Ty insertions that inactivate the function of the Saccharomyces cerevisiae CAN1 gene is reported. Under some selection condition Ty elements inserted preferentially into the promoter and exhibited an orientation bias. In contrast, under other conditions no insertions were detected in the promoter region and transposition apppeared to occur randomly throughout the CAN1 coding sequence. These results show that the target site distribution for Ty insertions may be a function of the selection conditions.