Rheologic properties of the erythrocytes and hemostatic system in patients with polycythemia vera
Bessmel'tsev, S.S.; Fedorova, Z.D.; Abdulkadyrov, K.M.
Gematologiia i Transfuziologiia 34(11): 29-33
1989
ISSN/ISBN: 0234-5730 PMID: 2612861 Document Number: 340898
Rheologic properties of red blood cells and hemostasis were investigated in 25 patients with polycythemia vera (PV). Manifest hemorheologic and hemocoagulation disorders attended by thrombohemorrhagic complications were revealed in this group of patients. It has been shown that hemorheologic disorders play an important role in the mechanisms of thrombohemorrhagic complications in PV, therefore they should be corrected with antiaggregation agents. In some cases disorders in the rheologic phenomena of red blood cells are a triggering mechanism in the development of disseminated intravascular coagulation (DIC) syndrome. A correlation has been revealed between the parameters of red blood cell rheologic properties and hemostasis and the disease severity. It is suggested that rheologic properties of red blood cells should be studied for the diagnosis of DIC syndrome.